解剖跟踪数据提供了有关脑电路的详细信息，这些信息对于解决扩散MRI拖拉术中的某些常见误差必不可少。然而，由于截断，噪声和伪影的存在以及强度/对比度变化，因此在跟踪数据上对纤维束的自动检测具有挑战性。在这项工作中，我们提出了一种具有自律损失函数的深度学习方法，该方法将基于解剖的损失函数构成了基于解剖学的约束，以准确地分割了猕猴大脑的示踪剂切片上的纤维束。同样，鉴于手动标签的可用性有限，我们使用半监督的培训技术有效地使用未标记的数据来改善性能和位置限制，以进一步降低误报。对不同猕猴的看不见的方法的评估，产生了令人鼓舞的结果，真正的正速率约为0.90。我们方法的代码可从https://github.com/v-sundaresan/fiberbundle_seg_tracing获得。

语言模型预训练的最新进展利用大规模数据集创建多语言模型。但是，这些数据集中大多遗漏了低资源语言。这主要是因为网络上没有很好地表示口语，因此被排除在用于创建数据集的大规模爬网中。此外，这些模型的下游用户仅限于最初选择用于预训练的语言的选择。这项工作调查了如何最佳利用现有的预培训模型来为16种非洲语言创建低资源翻译系统。我们关注两个问题：1）如何将预训练的模型用于初始预培训中未包含的语言？ 2）生成的翻译模型如何有效地转移到新域？为了回答这些问题，我们创建了一个新的非洲新闻语料库，涵盖16种语言，其中8种语言不属于任何现有评估数据集的一部分。我们证明，将两种语言转移到其他语言和其他领域的最有效策略是，以少量的高质量翻译数据微调大型预训练模型。

我们考虑半监督视频对象分段（VOS）的任务。我们的方法通过解决视觉翘曲的详细保存和时间一致性来减轻以前的VOS工作中的缺点。与使用完全光流的事先工作相比，我们介绍了一种新的前景目标视觉翘曲方法，了解来自VOS数据的流场。我们训练一个流模块，以使用两个弱监督损失捕获帧之间的详细运动。我们的对象翘曲前面的前景对象掩模在目标帧中的位置的术语方法使得具有快速运行时的详细掩模细化而不使用额外的流量监控。它也可以直接集成到最先进的分段网络中。在Davis17和Youtubevos基准测试中，我们优于不使用额外数据的最先进的脱机方法，以及使用额外数据的许多在线方法。定性地，我们还显示了我们的方法，以高细节和时间一致性产生分割。

This paper presents a machine learning approach to multidimensional item response theory (MIRT), a class of latent factor models that can be used to model and predict student performance from observed assessment data. Inspired by collaborative filtering, we define a general class of models that includes many MIRT models. We discuss the use of penalized joint maximum likelihood (JML) to estimate individual models and cross-validation to select the best performing model. This model evaluation process can be optimized using batching techniques, such that even sparse large-scale data can be analyzed efficiently. We illustrate our approach with simulated and real data, including an example from a massive open online course (MOOC). The high-dimensional model fit to this large and sparse dataset does not lend itself well to traditional methods of factor interpretation. By analogy to recommender-system applications, we propose an alternative "validation" of the factor model, using auxiliary information about the popularity of items consulted during an open-book exam in the course.

Real-world robotic grasping can be done robustly if a complete 3D Point Cloud Data (PCD) of an object is available. However, in practice, PCDs are often incomplete when objects are viewed from few and sparse viewpoints before the grasping action, leading to the generation of wrong or inaccurate grasp poses. We propose a novel grasping strategy, named 3DSGrasp, that predicts the missing geometry from the partial PCD to produce reliable grasp poses. Our proposed PCD completion network is a Transformer-based encoder-decoder network with an Offset-Attention layer. Our network is inherently invariant to the object pose and point's permutation, which generates PCDs that are geometrically consistent and completed properly. Experiments on a wide range of partial PCD show that 3DSGrasp outperforms the best state-of-the-art method on PCD completion tasks and largely improves the grasping success rate in real-world scenarios. The code and dataset will be made available upon acceptance.

Optical coherence tomography (OCT) captures cross-sectional data and is used for the screening, monitoring, and treatment planning of retinal diseases. Technological developments to increase the speed of acquisition often results in systems with a narrower spectral bandwidth, and hence a lower axial resolution. Traditionally, image-processing-based techniques have been utilized to reconstruct subsampled OCT data and more recently, deep-learning-based methods have been explored. In this study, we simulate reduced axial scan (A-scan) resolution by Gaussian windowing in the spectral domain and investigate the use of a learning-based approach for image feature reconstruction. In anticipation of the reduced resolution that accompanies wide-field OCT systems, we build upon super-resolution techniques to explore methods to better aid clinicians in their decision-making to improve patient outcomes, by reconstructing lost features using a pixel-to-pixel approach with an altered super-resolution generative adversarial network (SRGAN) architecture.

Using Structural Health Monitoring (SHM) systems with extensive sensing arrangements on every civil structure can be costly and impractical. Various concepts have been introduced to alleviate such difficulties, such as Population-based SHM (PBSHM). Nevertheless, the studies presented in the literature do not adequately address the challenge of accessing the information on different structural states (conditions) of dissimilar civil structures. The study herein introduces a novel framework named Structural State Translation (SST), which aims to estimate the response data of different civil structures based on the information obtained from a dissimilar structure. SST can be defined as Translating a state of one civil structure to another state after discovering and learning the domain-invariant representation in the source domains of a dissimilar civil structure. SST employs a Domain-Generalized Cycle-Generative (DGCG) model to learn the domain-invariant representation in the acceleration datasets obtained from a numeric bridge structure that is in two different structural conditions. In other words, the model is tested on three dissimilar numeric bridge models to translate their structural conditions. The evaluation results of SST via Mean Magnitude-Squared Coherence (MMSC) and modal identifiers showed that the translated bridge states (synthetic states) are significantly similar to the real ones. As such, the minimum and maximum average MMSC values of real and translated bridge states are 91.2% and 97.1%, the minimum and the maximum difference in natural frequencies are 5.71% and 0%, and the minimum and maximum Modal Assurance Criterion (MAC) values are 0.998 and 0.870. This study is critical for data scarcity and PBSHM, as it demonstrates that it is possible to obtain data from structures while the structure is actually in a different condition or state.

Many modern research fields increasingly rely on collecting and analysing massive, often unstructured, and unwieldy datasets. Consequently, there is growing interest in machine learning and artificial intelligence applications that can harness this `data deluge'. This broad nontechnical overview provides a gentle introduction to machine learning with a specific focus on medical and biological applications. We explain the common types of machine learning algorithms and typical tasks that can be solved, illustrating the basics with concrete examples from healthcare. Lastly, we provide an outlook on open challenges, limitations, and potential impacts of machine-learning-powered medicine.

Osteoarthritis (OA) is the most prevalent chronic joint disease worldwide, where knee OA takes more than 80% of commonly affected joints. Knee OA is not a curable disease yet, and it affects large columns of patients, making it costly to patients and healthcare systems. Etiology, diagnosis, and treatment of knee OA might be argued by variability in its clinical and physical manifestations. Although knee OA carries a list of well-known terminology aiming to standardize the nomenclature of the diagnosis, prognosis, treatment, and clinical outcomes of the chronic joint disease, in practice there is a wide range of terminology associated with knee OA across different data sources, including but not limited to biomedical literature, clinical notes, healthcare literacy, and health-related social media. Among these data sources, the scientific articles published in the biomedical literature usually make a principled pipeline to study disease. Rapid yet, accurate text mining on large-scale scientific literature may discover novel knowledge and terminology to better understand knee OA and to improve the quality of knee OA diagnosis, prevention, and treatment. The present works aim to utilize artificial neural network strategies to automatically extract vocabularies associated with knee OA diseases. Our finding indicates the feasibility of developing word embedding neural networks for autonomous keyword extraction and abstraction of knee OA.

Objective: Accurate visual classification of bladder tissue during Trans-Urethral Resection of Bladder Tumor (TURBT) procedures is essential to improve early cancer diagnosis and treatment. During TURBT interventions, White Light Imaging (WLI) and Narrow Band Imaging (NBI) techniques are used for lesion detection. Each imaging technique provides diverse visual information that allows clinicians to identify and classify cancerous lesions. Computer vision methods that use both imaging techniques could improve endoscopic diagnosis. We address the challenge of tissue classification when annotations are available only in one domain, in our case WLI, and the endoscopic images correspond to an unpaired dataset, i.e. there is no exact equivalent for every image in both NBI and WLI domains. Method: We propose a semi-surprised Generative Adversarial Network (GAN)-based method composed of three main components: a teacher network trained on the labeled WLI data; a cycle-consistency GAN to perform unpaired image-to-image translation, and a multi-input student network. To ensure the quality of the synthetic images generated by the proposed GAN we perform a detailed quantitative, and qualitative analysis with the help of specialists. Conclusion: The overall average classification accuracy, precision, and recall obtained with the proposed method for tissue classification are 0.90, 0.88, and 0.89 respectively, while the same metrics obtained in the unlabeled domain (NBI) are 0.92, 0.64, and 0.94 respectively. The quality of the generated images is reliable enough to deceive specialists. Significance: This study shows the potential of using semi-supervised GAN-based classification to improve bladder tissue classification when annotations are limited in multi-domain data.